Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations

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چکیده

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Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations

BACKGROUND Immunosenescence is a process that affects all cell compartments of the immune system and the contribution of the immune system to healthy aging and longevity is still an open question. Lymphocyte subpopulations present different patterns of circadian variation and in the elderly alteration of circadian rhythmicity has been evidenced. The aim of our study was to analyze the dynamics ...

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Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.

The mPer1, mPer2, mCry1, and mCry2 genes play a central role in the molecular mechanism driving the central pacemaker of the mammalian circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus. In vitro studies suggest a close interaction of all mPER and mCRY proteins. We investigated mPER and mCRY interactions in vivo by generating different combinations of mPer/mCry dou...

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ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS

Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...

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Extent of cerebral white matter lesions is related to changes of circadian blood pressure rhythmicity.

OBJECTIVE To evaluate the relationship between circadian blood pressure patterns and the extent of cerebral white matter lesions (WML). DESIGN Case-control study. PARTICIPANTS A total of 227 healthy subjects older than 55 years were investigated. Extent and occurrence of WML were evaluated using a computer-supported image analysis system. Circadian blood pressure variation was defined as th...

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ژورنال

عنوان ژورنال: Journal of Circadian Rhythms

سال: 2010

ISSN: 1740-3391

DOI: 10.1186/1740-3391-8-6